Protein Details: Cation channel sperm-associated protein 1
Protein ID
ICDB_Pro_1285
Protein Name
Cation channel sperm-associated protein 1
Gene Name
CATSPER1
Organism
Homo sapiens (Human)
Length
780 amino acids
AlphaFoldDB
AF-Q8NEC5-F1-model_v4.pdb
Function
Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization; such as sperm hyperactivation; acrosome reaction and chemotaxis towards the oocyte.
Sequence
MDQNSVPEKAQNEADTNNADRFFRSHSSPPHHRPGHSRALHHYELHHHGVPHQRGESHHPPEFQDFHDQALSSHVHQSHHHSEARNHGRAHGPTGFGLAPSQGAVPSHRSYGEDYHDELQRDGRRHHDGSQYGGFHQQSDSHYHRGSHHGRPQYLGENLSHYSSGVPHHGEASHHGGSYLPHGPNPYSESFHHSEASHLSGLQHDESQHHQVPHRGWPHHHQVHHHGRSRHHEAHQHGKSPHHGETISPHSSVGSYQRGISDYHSEYHQGDHHPSEYHHGDHPHHTQHHYHQTHRHRDYHQHQDHHGAYHSSYLHGDYVQSTSQLSIPHTSRSLIHDAPGPAASRTGVFPYHVAHPRGSAHSMTRSSSTIRSRVTQMSKKVHTQDISTKHSEDWGKEEGQFQKRKTGRLQRTRKKGHSTNLFQWLWEKLTFLIQGFREMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEALLKIIALGLSYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQSLFRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAVLRALFRKSDPKRFQNIFTTIFTLFTLLTLDDWSLIYMDSRAQGAWYIIPILVIYIIIQYFIFLNLVITVLVDSFQTALFKGLEKAKQERAARIQEKLLEDSLTELRAAEPKEVASEGTMLKRLIEKKFGTMTEKQQELLFHYLQLVASVEQEQQKFRSQAAVIDEIVDTTFEAGEEDFRN
PDB Structures
Ligand Binding
Binding Site
Disease
Spermatogenic Failure 7 and Non-Syndromic Male Infertility Due To Sperm Motility Disorder
Location
Testis-specific
DOI ID
10.1038/35098027; 10.1038/nature04632; 10.1101/gr.2596504; 10.1093/humrep/deh043; 10.1111/j.1745-7262.2006.00132.x; 10.1074/jbc.m511288200; 10.1093/molehr/gam009; 10.1016/j.ajhg.2009.03.004; 10.1038/nature09769; 10.1038/nature09767; 10.1126/science.aad6887
RefSeq
NP_444282.3